., 2000). This sparing of CB1 receptors adhering to peripheral nerve injury could show a possible therapeutic advantage of cannabinoids over opioids from the remedy of neuropathic soreness. This hypothesis is even further supported by a current analyze (Mao et al
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the CB1 receptor. Administration of SR141716a alone had no have an impact on within the noticed allodynia and hyperalgesia, which will not aid the idea of the endogenous analgesic tone.
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This result was prevented by co-administration on the CB1 receptor antagonist SR141716a, but not by co-administration from the CB2 receptor antagonist SR144528, suggesting this action of WIN55,212-2 is mediated by using
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